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site map | enhanced glossary |
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NF1
is a hereditary disorder due to an alteration, called a
mutation,
in the NF1 gene.
All people have two copies of every gene, one copy inherited from each parent. The NF1 gene
mutation is dominant, meaning only one of the two copies of the gene
needs to have the mutation to produce the disorder. A parent with NF1
has a 50% chance of passing the abnormal gene copy to a
child. A child who inherits the altered gene will also have
the disorder. The Inheritance animation below illustrates
how this occurs.
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